Suspected adverse reactions should be reported to Shire at: drugsafety@shire.com

Please see full EU Prescribing Information.

References:

1. Kaplan AP. Enzymatic pathways in the pathogenesis of hereditary angioedema: the role of C1 inhibitor therapy. J Allergy Clin Immunol. 2010;126(5):918-925. 2. Bygum A, Aygören-Pürsün E, Beusterien K, et al. Burden of illness in hereditary angioedema: a conceptual model. Acta Derm Venereol. 2015;95(6):706-710. 3. Caballero T, Aygören-Pürsün E, Bygum A, et al. The humanistic burden of hereditary angioedema: results from the Burden of Illness Study in Europe. Allergy Asthma Proc. 2014;35(1):47-53. 4. Maurer M, Magerl M, Ansotegui I, et al. The international WAO/EAACI guideline for the management of hereditary angioedema –the 2017 revision and update. Allergy. 2018. https://doi.org/10.1111/all.13384. Published online January 10, 2018. 5. TAKHZYRO (lanadelumab) Summary of Product Characteristics. November 2018. 6. Banerji A, Riedl MA, Bernstein JA, et al; for the HELP Investigators. Effect of lanadelumab compared with placebo on prevention of hereditary angioedema attacks: a randomized clinical trial. JAMA. 2018;320(20):2108-2121. 7. Kenniston J, Faucette RR, Martik D, et al. Inhibition of plasma kallikrein by a highly specific active site blocking antibody. J Biol Chem. 2014;289(34):23596-23608. 8. Schmaier AH. Plasma prekallikrein: its role in hereditary angioedema and health and disease. Front Med. 2018;5(3):1-6. 9. Schneider L, Lumry W, Vegh A, et al. Critical role of kallikrein in hereditary angioedema pathogenesis: a clinical trial of ecallantide, a novel kallikrein inhibitor. J Allergy Clin Immunol. 2007;120(2):416-422. 10. Weller K, Groffik A, Magerl M, et al. Development and construct validation of the angioedema quality of life questionnaire. Allergy. 2012;67(10):1289-1298. 11. AE-QoL: angioedema quality of life questionnaire for patients with recurrent swelling episodes. American English version 2012. Moxie GmbH website. http://moxie-gmbh.de/media/pdf/ae-qol_scoringsystem_moxie.pdf. Accessed November 28, 2018.